Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
s1pr5_human 393 C-term S => Ter stop gained 0.000724 85 117410 1 None None PTM (Phosphorylation)
s1pr5_human 299 7.46x46 TM7 S => Ter stop gained 8.793e-06 1 113724 0 None None PTM (Phosphorylation)
s1pr5_human 21 N-term Y => AlafsTer? frameshift 0.001167 117 100294 0 None None
s1pr5_human 394 C-term E => K missense 0.0002724 32 117470 0 nan 0.0
s1pr5_human 390 C-term T => A missense 2.568e-05 3 116822 0 nan 0.002
s1pr5_human 388 C-term A => D missense 8.584e-05 10 116492 0 0.02 0.001
s1pr5_human 385 C-term P => T missense 4.348e-05 5 114996 0 0.1 0.073
s1pr5_human 384 C-term A => V missense 1.742e-05 2 114794 0 0.26 0.002
s1pr5_human 383 C-term G => S missense 1.761e-05 2 113572 0 0.06 0.002
s1pr5_human 372 C-term G => R missense 2.721e-05 3 110234 0 0.08 0.004
s1pr5_human 371 C-term D => V missense 9.136e-06 1 109462 0 0.0 0.329
s1pr5_human 371 C-term D => H missense 1.847e-05 2 108262 0 0.0 0.649
s1pr5_human 370 C-term R => H missense 9.243e-06 1 108192 0 0.36 0.002
s1pr5_human 370 C-term R => S missense 9.262e-06 1 107964 0 0.27 0.04
s1pr5_human 369 C-term Q => H missense 9.298e-06 1 107552 0 0.04 0.002
s1pr5_human 369 C-term Q => R missense 5.612e-05 6 106916 0 0.56 0.001
s1pr5_human 368 C-term P => L missense 1.911e-05 2 104682 0 0.04 0.133
s1pr5_human 366 C-term S => L missense 5.103e-05 5 97982 0 0.13 0.005
s1pr5_human 365 C-term R => P missense 1.054e-05 1 94846 0 0.17 0.002
s1pr5_human 363 C-term S => W missense 2.029e-05 2 98550 0 0.0 0.818
s1pr5_human 359 C-term S => R missense 4.197e-05 4 95314 0 0.03 0.994
s1pr5_human 358 C-term G => E missense 1.067e-05 1 93686 0 0.33 0.024
s1pr5_human 354 C-term P => L missense 1.115e-05 1 89668 0 0.04 0.007
s1pr5_human 350 C-term R => H missense 9.421e-05 8 84918 1 0.06 0.001
s1pr5_human 346 C-term G => E missense 1.192e-05 1 83906 0 0.06 0.004
s1pr5_human 339 C-term A => V missense 1.197e-05 1 83522 0 0.52 0.028
s1pr5_human 335 C-term S => C missense 1.14e-05 1 87682 0 0.03 0.395
s1pr5_human 333 C-term S => T missense 1.105e-05 1 90532 0 0.44 0.014
s1pr5_human 329 C-term G => S missense 1.015e-05 1 98480 0 0.91 0.002
s1pr5_human 328 C-term C => W missense 1.008e-05 1 99188 0 0.05 0.005
s1pr5_human 324 C-term G => R missense 0.0002515 27 107348 0 0.28 0.401
s1pr5_human 318 8.55x55 H8 L => Q missense 0.03302 3695 111908 114 0.0 0.917
s1pr5_human 315 8.52x52 H8 H => Q missense 8.88e-06 1 112616 0 0.05 0.002
s1pr5_human 314 8.51x51 H8 R => C missense 8.85e-06 1 112988 0 0.0 0.997 GP (contact)
s1pr5_human 312 8.49x49 H8 D => N missense 0.0001323 15 113416 0 0.0 0.998 GP (contact)
s1pr5_human 311 8.48x48 H8 R => H missense 3.525e-05 4 113476 0 0.0 0.617 GP (contact)
s1pr5_human 308 7.55x55 TM7 L => H missense 0.001571 179 113976 2 0.0 0.807 GP (contact)
s1pr5_human 308 7.55x55 TM7 L => F missense 8.771e-06 1 114008 0 0.09 0.007 GP (contact)
s1pr5_human 307 7.54x54 TM7 T => M missense 5.261e-05 6 114050 0 0.0 0.998
s1pr5_human 307 7.54x54 TM7 T => S missense 8.769e-06 1 114040 0 0.0 0.99
s1pr5_human 301 7.48x48 TM7 L => P missense 8.775e-06 1 113958 0 0.0 1.0
s1pr5_human 301 7.48x48 TM7 L => V missense 1.756e-05 2 113888 0 0.04 0.999
s1pr5_human 289 7.36x35 TM7 D => N missense 1.794e-05 2 111480 0 0.07 0.999 LB (polar (charge-assisted hydrogen bond), polar (hydrogen bond with backbone))
s1pr5_human 284 7.31x30 TM7 V => I missense 0.004983 545 109380 3 0.96 0.044
s1pr5_human 281 ECL3 T => A missense 9.36e-06 1 106840 0 1.0 0.0
s1pr5_human 279 ECL3 A => V missense 9.548e-06 1 104738 0 0.97 0.687
s1pr5_human 278 ECL3 P => L missense 9.584e-06 1 104340 0 0.04 1.0
s1pr5_human 277 6.61x61 TM6 C => Y missense 8.776e-05 9 102550 0 0.01 0.999
s1pr5_human 276 6.60x60 TM6 A => S missense 1.98e-05 2 101002 0 0.21 0.531
s1pr5_human 274 6.58x58 TM6 D => Y missense 1.021e-05 1 97970 0 0.0 1.0
s1pr5_human 258 6.42x42 TM6 L => P missense 7.652e-05 5 65346 0 0.22 0.021
s1pr5_human 257 6.41x41 TM6 L => R missense 1.587e-05 1 63026 0 0.0 0.9
s1pr5_human 250 6.34x34 TM6 L => Q missense 2.24e-05 1 44650 0 0.0 1.0 SodiumPocket MicroSwitch
s1pr5_human 248 6.32x32 TM6 A => T missense 2.536e-05 1 39436 0 0.01 0.906 GP (contact)
s1pr5_human 245 6.29x29 TM6 R => C missense 2.942e-05 1 33990 0 0.0 0.963 GP (contact)
s1pr5_human 237 ICL3 S => W missense 3.818e-05 1 26194 0 0.0 0.772
s1pr5_human 236 ICL3 T => N missense 3.85e-05 1 25972 0 0.53 0.057
s1pr5_human 234 5.80x80 TM5 G => R missense 3.927e-05 1 25462 0 0.42 0.007
s1pr5_human 231 5.77x77 TM5 G => R missense 7.972e-05 2 25088 0 0.23 0.012
s1pr5_human 221 5.67x67 TM5 A => T missense 3.967e-05 1 25210 0 0.52 0.584 GP (contact)
s1pr5_human 219 5.65x65 TM5 V => A missense 3.554e-05 1 28134 0 0.0 0.996 GP (contact)
s1pr5_human 219 5.65x65 TM5 V => I missense 0.001923 55 28600 0 0.0 0.996 GP (contact)
s1pr5_human 217 5.63x63 TM5 C => F missense 3.254e-05 1 30728 0 0.76 0.23
s1pr5_human 213 5.59x59 TM5 A => E missense 2.593e-05 1 38572 0 0.0 0.832
s1pr5_human 212 5.58x58 TM5 Y => H missense 2.31e-05 1 43282 0 0.0 0.997 SodiumPocket MicroSwitch
s1pr5_human 207 5.53x53 TM5 A => S missense 1.097e-05 1 91148 0 0.39 0.711
s1pr5_human 200 5.46x46 TM5 A => P missense 3.302e-05 3 90856 0 0.0 0.783
s1pr5_human 199 5.45x45 TM5 L => V missense 3.31e-05 3 90622 0 0.07 0.021
s1pr5_human 194 5.40x40 TM5 V => L missense 1.125e-05 1 88908 0 0.1 0.998
s1pr5_human 192 5.38x38 TM5 A => T missense 1.135e-05 1 88104 0 0.59 0.424
s1pr5_human 190 5.36x36 TM5 A => T missense 1.161e-05 1 86158 0 0.34 0.989
s1pr5_human 179 ECL2 L => P missense 5.402e-05 4 74044 0 0.0 1.0
s1pr5_human 178 ECL2 R => H missense 1.359e-05 1 73578 0 0.25 0.006
s1pr5_human 178 ECL2 R => L missense 1.359e-05 1 73578 0 0.25 0.353
s1pr5_human 170 4.61x61 TM4 A => E missense 1.613e-05 1 62014 0 0.01 0.389
s1pr5_human 170 4.61x61 TM4 A => S missense 1.609e-05 1 62132 0 0.13 0.012
s1pr5_human 161 4.52x52 TM4 V => M missense 4.474e-05 2 44704 0 0.03 0.354
s1pr5_human 155 4.46x46 TM4 A => P missense 2.551e-05 1 39198 0 0.0 0.93
s1pr5_human 154 4.45x45 TM4 M => I missense 2.541e-05 1 39350 0 0.0 0.015
s1pr5_human 151 4.42x42 TM4 T => A missense 2.688e-05 1 37196 0 0.16 0.004
s1pr5_human 148 4.39x39 TM4 R => W missense 2.738e-05 1 36518 0 0.03 0.071
s1pr5_human 147 4.38x38 TM4 S => C missense 8.195e-05 3 36608 0 0.0 0.733
s1pr5_human 141 34.51x51 ICL2 G => A missense 2.759e-05 1 36244 0 0.06 0.04 GP (contact)
s1pr5_human 129 3.46x46 TM3 I => V missense 4.132e-05 2 48406 0 0.02 0.019
s1pr5_human 127 3.44x44 TM3 L => P missense 1.972e-05 1 50702 0 0.0 1.0
s1pr5_human 123 3.40x40 TM3 V => M missense 1.725e-05 1 57958 0 0.0 0.685 SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals)
s1pr5_human 121 3.38x38 TM3 A => E missense 1.628e-05 1 61434 0 0.0 0.999
s1pr5_human 117 3.34x34 TM3 V => A missense 0.0005397 37 68552 0 0.07 0.032
s1pr5_human 111 3.28x28 TM3 R => L missense 3.935e-05 3 76234 0 0.0 0.999 LB (polar (charge-assisted hydrogen bond))
s1pr5_human 106 3.23x23 TM3 A => V missense 9.785e-05 8 81758 0 0.43 0.59
s1pr5_human 77 2.45x45 TM2 S => R missense 9.338e-06 1 107090 0 0.0 0.966
s1pr5_human 73 2.41x41 TM2 L => P missense 0.0001935 21 108546 0 0.0 0.952
s1pr5_human 72 2.40x40 TM2 F => L missense 9.206e-06 1 108626 0 0.0 0.349
s1pr5_human 71 2.39x39 TM2 M => V missense 1.837e-05 2 108892 0 0.0 0.983
s1pr5_human 66 12.49x49 ICL1 R => L missense 2.747e-05 3 109200 0 0.0 0.909
s1pr5_human 63 1.59x59 TM1 R => L missense 1.823e-05 2 109738 0 0.0 0.664
s1pr5_human 60 1.56x56 TM1 V => A missense 0.0002798 31 110788 1 1.0 0.024
s1pr5_human 57 1.53x53 TM1 V => M missense 2.697e-05 3 111216 0 0.0 0.999
s1pr5_human 44 1.40x40 TM1 L => P missense 8.877e-06 1 112652 0 0.0 0.999
s1pr5_human 43 1.39x39 TM1 C => F missense 8.907e-06 1 112272 0 1.0 0.983 LB (Van der Waals)
s1pr5_human 42 1.38x38 TM1 V => L missense 8.923e-06 1 112076 0 nan 0.893
s1pr5_human 41 1.37x37 TM1 V => L missense 5.372e-05 6 111680 0 0.1 0.119
s1pr5_human 39 1.35x35 TM1 D => E missense 8.95e-06 1 111728 0 nan 0.984
s1pr5_human 39 1.35x35 TM1 D => N missense 2.688e-05 3 111592 0 nan 0.982
s1pr5_human 35 N-term G => D missense 1.803e-05 2 110940 0 nan 0.999
s1pr5_human 33 N-term G => V missense 9.006e-06 1 111038 0 nan 0.999
s1pr5_human 32 N-term P => S missense 1.805e-05 2 110834 0 nan 0.986
s1pr5_human 27 N-term G => S missense 9.051e-06 1 110490 0 nan 0.994
s1pr5_human 27 N-term G => C missense 9.051e-06 1 110490 0 nan 0.999
s1pr5_human 26 N-term R => C missense 9.067e-06 1 110296 0 nan 0.988
s1pr5_human 23 N-term G => V missense 2.724e-05 3 110146 0 0.0 0.999
s1pr5_human 23 N-term G => S missense 0.0001816 20 110140 1 0.0 0.999
s1pr5_human 23 N-term G => C missense 9.079e-06 1 110140 0 0.0 1.0
s1pr5_human 18 N-term H => Y missense 9.181e-06 1 108924 0 0.0 0.99
s1pr5_human 16 N-term V => A missense 9.237e-06 1 108266 0 nan 0.008
s1pr5_human 12 N-term S => T missense 9.529e-06 1 104946 0 nan 0.916
s1pr5_human 10 N-term P => L missense 9.639e-06 1 103740 0 nan 0.992
s1pr5_human 10 N-term P => R missense 9.639e-06 1 103740 0 nan 0.997


Residue

Diagrams

ICL1 P R F H ICL1ECL1 G P L T L K L ECL1ICL2 R G P A P V S ICL2ECL2 W N C L G R L D A C S T V L P L Y ECL2ICL3 T T S T ICL3ECL3 P A R T C ECL3N-term M E S G L L R P A P V S E V I V L H Y N Y T G K L R G A R Y Q P G A G L N-termC-term C G R H S C G R D P S G S Q Q S A S A A E A S G G L R R C L P P G L D G S F S G S E R S S P Q R D G L D T S G S T G S P G A P T A A R T L V S E P A A D C-term R A D A V V C L A V C A F I V L E N L A V L L V L G R H A P M F L L L G S L T L S D L L A G A A Y A A N I L L S S P A L W F A R E G G V F V A L T A S V L S L L A I A L E R S L T M A R S R G R T L A M A A A A W G V S L L L G L L P A L G A K A Y V L F C V L A F V G I L A A I C A L Y A R I Y C Q V R A N A R R L P A R P G T A G R A R R K P R S L A L L R T L S V V L L A F V A C W G P L F L L L L L D V A C P V L L Q A D P F L G L A M A N S L L N P I I Y T L T N R D L L R L R H A L V C
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